HOLYOKE — Three men are facing drug charges after police searched two Newton Street addresses and two vehicles associated with them and seized large quantities of fentanyl and cocaine, an unlicensed firearm, ammunition and over $25,000 in cash, Holyoke police reported Tuesday.

Eric Ramos Berrios and Antonio Luis Perez Gonzalez were both charged with possession of and possession with intent to distribute a class A drug (fentanyl). Miguel Gonzalez Cruz was charged with trafficking a class A drug (heroin), 18 to 36 grams, possession of and possession with intent to distribute a class B drug, possession of a firearm in the commission of a felony, possession of ammunition and possession of a firearm without an FID card or license. All were charged with conspiracy to violate drug laws.

The execution of the search warrant, by Holyoke police and the Hampden County Sheriff’s Department, was the culmination of a monthslong investigation targeting an open-air fentanyl and cocaine trafficking operation at 103 and 107 Newton St., police said.