CHICAGO — Pablo Sandoval hit a tiebreaking single in Boston’s four-run sixth inning and Drew Pomeranz struck out eight in his second straight win, helping the Red Sox beat the Chicago White Sox 4-1 on Wednesday night.

Sandoval went 3 for 4 in his first game since he was activated from the disabled list Tuesday after being sidelined by a sprained right knee. It was an encouraging sign for the Red Sox, in need of some help at the plate with Dustin Pedroia sidelined by a sprained left wrist.

Chicago wasted a great start by Mike Pelfrey in its second consecutive loss after winning four of five. The big right-hander struck out five while pitching five scoreless innings of two-hit ball, leaving him with a 1.13 ERA over his last three games.

Anthony Swarzak (2-1) replaced Pelfrey, and the Red Sox jumped all over him, loading the bases with one out in the sixth. Josh Rutledge beat out a potential double-play grounder, tying it at 1, and Sandoval followed a single to left.

After the runners moved up on a wild pitch, Christian Vazquez hit a two-run double into left-center to give Boston a 4-1 lead. Swarzak had allowed just three earned runs in 23 1/3 innings this season coming into the game.

That was more than enough for Pomeranz (5-3), who allowed one run and seven hits in a season-high seven innings. The left-hander also pitched well in his previous start, striking out 11 over six innings in a 6-2 victory against Texas.

Matt Barnes tossed a perfect eighth before Craig Kimbrel struck out the side for his 15th save in 16 chances, finishing Boston’s eighth win in 10 games. Kimbrel also saved Tuesday’s 13-7 victory, throwing 27 pitches while pitching 1 1/3 innings.

Tim Anderson and Avisail Garcia had two hits apiece for the White Sox, who closed out a 4-3 homestand. Anderson doubled home Garcia in the second.

HE GONE — White Sox broadcaster Ken “Hawk” Harrelson announced he plans to retire after doing 20 games next year in his 34th season in the booth. Harrelson, a colorful character known for his folksy sayings and unbridled enthusiasm for his longtime team, will work primarily Sunday home games in 2018. After he finishes his TV duties, the 75-year-old Harrelson will serve as a team ambassador for the 2019 season.

TRAINER’S ROOM — Red Sox RHP Carson Smith (Tommy John surgery) is progressing toward facing hitters Tuesday in New York, according to manager John Farrell.

UP NEXT — Red Sox LHP Eduardo Rodriguez (4-1, 2.77 ERA) faces Orioles LHP Wade Miley (1-3, 3.02 ERA) on Thursday night in the opener of a four-game set at Baltimore. After the series against the Orioles, the Red Sox finish off their 10-game trip with three against the Yankees.

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